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A monkey antigen crossreacting with carcinoembryonic antigen, CEA

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Abstract

Normal monkey tissues were found to contain an antigen which crossreacts immunologically with the carcinoembryonic antigen (CEA) of the human digestive tract. The monkey antigen reacted with complete or partial identity to the normal crossreacting antigen (NCA) in humans when tested in immunodiffusion against anti-CEA or anti-NCA. Extracts of monkey tissues inhibited in radioimmunoassays measuring human NCA. It is possible that monkey foetuses and colonic tumours contain CEA.

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Authors
  1. E Engvall
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  2. M Vuento
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  3. E Ruoslahti
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Additional information

This work was supported by the Finnish Medical Research Council, the Cilag-Chemie Foundation, and the National Cancer Instittute (Grant No. CA 16434).

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Engvall, E., Vuento, M. & Ruoslahti, E. A monkey antigen crossreacting with carcinoembryonic antigen, CEA. Br J Cancer 34, 341–345 (1976). https://doi.org/10.1038/bjc.1976.176

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  • DOI: https://doi.org/10.1038/bjc.1976.176

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