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Defining polyubiquitin chain topology

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Recent crystal structures suggest models for how an asymmetric E2/E2-like protein complex synthesizes a polyubiquitin chain that functions in DNA repair and NF-κB activation pathways.

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Figure 2: Structure of the Ubc13–Mms2 complex.

References

  1. Koepp, D.M., Harper, J.W. & Elledge, S.J. Cell 97, 431– 434 (1999).

    Article  CAS  Google Scholar 

  2. Joazeiro, C.A. & Weissman, A.M. Cell 102, 549– 552 (2000).

    Article  CAS  Google Scholar 

  3. Hicke, L. Nature Rev. Mol. Cell Biol. 2, 195– 201 (2001).

    Article  CAS  Google Scholar 

  4. Rock, K.L. & Goldberg, A.L. Annu. Rev. Immunol. 17, 739– 779 (1999).

    Article  CAS  Google Scholar 

  5. Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425– 479 (1998).

    Article  CAS  Google Scholar 

  6. Pickart, C.M. Annu. Rev. Biochem. 70, 503– 533 (2001).

    Article  CAS  Google Scholar 

  7. Pickart, C.M. Trends Biochem. Sci. 25, 544– 548 (2000).

    Article  CAS  Google Scholar 

  8. Hofmann, R.M. & Pickart, C.M. Cell 96, 645– 653 (1999).

    Article  CAS  Google Scholar 

  9. Deng, L. et al. Cell 103, 351– 361 (2000).

    Article  CAS  Google Scholar 

  10. Spense, J. et al. Cell 102, 67– 76 (2000).

    Article  Google Scholar 

  11. Galan J, & Haguenauer-Tsapis R. EMBO J. 19, 5847– 5854 (1997).

    Article  Google Scholar 

  12. Spense, J., Sadis, S., Haas, A.L. & Finley, D. Mol. Cell. Biol. 15, 1265– 1273 (1995).

    Article  Google Scholar 

  13. Moraes, T.F. et al. Nature Struct. Biol. 8, 669– 673 (2001).

    Article  CAS  Google Scholar 

  14. VanDemark, A.P., Hofmann, R.M., Tsui, C., Pickart, C.M. & Wolberger, C.M. Cell 105, 711– 720 (2001).

    Article  CAS  Google Scholar 

  15. Zheng, N., Wang, P., Jeffrey & P.D., Pavletich Cell 102, 533– 539 (2000).

    Article  CAS  Google Scholar 

  16. Huang, L. et al. Science 286, 1321– 1326 (1999).

    Article  CAS  Google Scholar 

  17. Ptak, C. et al. J. Biol. Chem. 269, 26539– 26545 (1994).

    CAS  PubMed  Google Scholar 

  18. Chen, P., Johnson, P., Sommer, T., Jentsch, S. & Hochstrasser, M. Cell 74, 357– 369 (1993)

    Article  CAS  Google Scholar 

  19. Sancho, E. et al. Mol. Cell. Biol. 18, 576– 589 (1998).

    Article  CAS  Google Scholar 

  20. Xiao, W., Lin, S.L., Broomfield, S., Chow, B.L., & Wei, Y.F. Nucleic Acids Res. 26, 3908– 3914 (1998).

    Article  CAS  Google Scholar 

  21. Glover, J.N. & Harrison, S.C., Nature 373, 257– 261 (1995).

    Article  CAS  Google Scholar 

  22. Chen, F.E., Huang, D.B., Chen, Y.Q. & Ghosh, G., Nature 391, 410– 413 (1998).

    Article  CAS  Google Scholar 

  23. Miura, T., Klaus, W., Gsell, B., Miyamoto, C. & Senn, H. J. Mol. Biol. 290, 213– 228 (1999).

    Article  CAS  Google Scholar 

  24. Liu, Q. et al. J. Biol. Chem. 274, 16979– 16987 (1999).

    Article  CAS  Google Scholar 

  25. Ulrich, H.D. & Jentsch, S. EMBO J. 19, 3388– 3397 (2000).

    Article  CAS  Google Scholar 

  26. Wang, C. et al. Nature, in the press (2001).

  27. Babst, M., Odorizzi, G., Estepa, E.J. & Emr, S.D. Traffic 1, 248– 258 (2000).

    Article  CAS  Google Scholar 

  28. VerPlank, L. et al. Proc. Natl. Acad. Sci. U.S.A. 98, 7724– 7729 (2001).

    Article  CAS  Google Scholar 

  29. Koonin, E.V. & Abagyan, R.A. Nature Genet. 16, 330– 331 (1997).

    Article  CAS  Google Scholar 

  30. Ponting, C.P., Cai, Y.D. & Bork, P. J. Mol. Med. 75, 467– 469 (1997).

    Article  CAS  Google Scholar 

  31. Koegl, M. et al. Cell 96, 635– 644 (1999).

    Article  CAS  Google Scholar 

  32. Hofmann, K. & Falquet, L. Trends Biochem. Sci. 26, 347– 350 (2001).

    Article  CAS  Google Scholar 

  33. Bertollaet, B.L. et al. Nature Struc. Biol. 8, 417– 422 (2001).

    Article  Google Scholar 

  34. Wilkinson, K.D. Semin. Cell Dev. Biol. 11, 141– 148 (2000).

    Article  CAS  Google Scholar 

  35. Carson, M. Macromol. Crystallogr. B 277, 493– 505 (1997).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. the Institute of Biochemistry, College of Life Sciences, National Chung Hsing University, Taichung City, 40227, Taiwan

    Nei-Li Chan

  2. the Department of Biochemistry, University of Utah School of Medicine, 50 N. Medical Drive, Salt Lake City, 84132, Utah, USA

    Christopher P. Hill

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  1. Nei-Li Chan
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  2. Christopher P. Hill
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Correspondence to Christopher P. Hill.

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Chan, NL., Hill, C. Defining polyubiquitin chain topology. Nat Struct Mol Biol 8, 650–652 (2001). https://doi.org/10.1038/90337

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