If known pathways represent preferred paths through global protein networks, large-scale experiments should focus on how to recognize these paths among all of the alternatives.
References
Idekar, T. et al. Science 292, 929–934 (2001).
Gygi, S.P., Rochon, Y., Franza, B.R. & Aebersold, R. Mol. Cell. Biol. 19, 1720–1730 (1999).
Pasternack, L.B., Laude, D.A. Jr. & Appling, D.R. Biochemistry 33, 7166–7173 (1994).
Fiehn, O. et al. Nat. Biotechnol. 18, 1157–1161 (2000).
Uetz, P. et al. Nature 403, 623–627 (2000).
Ito, T. et al. Proc. Natl. Acad. Sci. USA 98, 4569–4574 (2001).
Xenarios, I., et al. Nucleic Acids Res. 29, 239–241 (2001).
Marcotte, E.M., Pellegrini, M., Thompson, M.J., Yeates, T.O. & Eisenberg. D. Nature 402, 83–86 (1999).
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Marcotte, E. The path not taken. Nat Biotechnol 19, 626–627 (2001). https://doi.org/10.1038/90222
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DOI: https://doi.org/10.1038/90222
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