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Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

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Abstract

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.

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Figure 1: FISH of metaphase chromosomes (left panels) and interphase nuclei (right panels) of t(1;22)-containing leukemia cells.
Figure 2: RBM15, MKL1 and reciprocal fusions in t(1;22).

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Acknowledgements

We thank C. Lee, IWK Grace Health Centre, Halifax, NS, and E. Separovic, British Columbia Children's Hospital, Vancouver, BC, Canada, for help in identifying leukemia cell samples; J. Skaug and The Centre for Applied Genomics at The Hospital for Sick Children for excellent technical assistance; I. Herrington and V. Audino for manuscript preparation; and J. Downing and J. Dick for comments regarding the manuscript. This research was supported in part by grant CA-87064 (to S.W.M.) and Cancer Center Support (CORE) grant CA-27165, both from the National Cancer Institute, by the American Lebanese Syrian Associated Charities (ALSAC), St Jude Children's Research Hospital, and by The Hospital for Sick Children Foundation. S.W.S. is the recipient of a CIHR Scholar Award.

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Authors and Affiliations

  1. Department of Pathology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA

    Zhigui Ma, Stephan W. Morris & Xiaoli Cui

  2. Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA

    Virginia Valentine

  3. Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA

    Stephan W. Morris

  4. Hartwell Center for Bioinformatics and Biotechnology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA

    Perdeep K. Mehta

  5. Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, 38163, Tennessee, USA

    Stephan W. Morris

  6. Centre for Applied Molecular Biology, School of Pharmacy, University of London, WC1N 1AX, UK

    Dean Nizetic

  7. Department of Cancer Chemotherapy, Saitama Cancer Center Hospital, Ina, 363-0806, Saitama, Japan

    Yasuhiko Kaneko

  8. Department of Paediatrics, Division of Haematology, Queen Mary Hospital, University of Hong Kong, PRC

    Godfrey C.F. Chan

  9. Department of Pathology, Division of Haematology, Queen Mary Hospital, University of Hong Kong, PRC

    Li C. Chan

  10. Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Ontario, Canada

    Johann K. Hitzler

  11. Department of Cancer and Blood, The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Ontario, Canada

    Yue Li & Johann K. Hitzler

  12. Department of Genetics, The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Ontario, Canada

    Martin L, Jo-Anne Herbrick & Stephen W. Scherer

  13. Department of Medical Biophysics, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Jeremy Squire

  14. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Derek Bouman & Jeremy Squire

  15. Department of Molecular and Medical Genetics, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Stephen W. Scherer

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  1. Zhigui Ma
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  2. Stephan W. Morris
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  3. Virginia Valentine
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  4. Martin L
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  5. Jo-Anne Herbrick
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  6. Xiaoli Cui
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  7. Derek Bouman
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  8. Yue Li
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  9. Perdeep K. Mehta
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  10. Dean Nizetic
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  11. Yasuhiko Kaneko
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  12. Godfrey C.F. Chan
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  13. Li C. Chan
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  14. Jeremy Squire
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  15. Stephen W. Scherer
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  16. Johann K. Hitzler
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Corresponding authors

Correspondence to Stephan W. Morris or Johann K. Hitzler.

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Ma, Z., Morris, S., Valentine, V. et al. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28, 220–221 (2001). https://doi.org/10.1038/90054

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  • DOI: https://doi.org/10.1038/90054

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