Large-scale mutagenesis of the mouse genome is an essential task associated with the Human Genome Project. The two opposing schools of direct and reverse genetics have demonstrated comparable advantages, and yet large numbers of mutant lines have mostly been the prerogative of direct genetics. An improved gene-trapping resource now brings reverse genetics one step closer.
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References
International Human Genome Sequencing Consortium. Nature 409, 860–921 (2001).
Venter J.C. et al. Science 291, 1304–1351 (2001).
Nolan, P.M. et al. Nature Genet. 25, 440–443 (2000).
De Angelis M.H. et al. Nature Genet. 25, 444–447 (2000).
Mitchell, K.J. et al. Nature Genet . 28,241–249 (2001).
Gossler, A. et al. Science 244, 463–465 (1989).
Freidrich, G. & Soriano, P. Genes Dev. 5, 1515–1523 (1991).
Von Melchmer, H. et al. Genes Dev. 6, 919–927 (1992).
Hicks, G.G. et al. Nature Genet. 16, 338–344 (1997).
Zambrowicz, B.P. et al. Nature 392, 608–611 (1998).
Wiles, M.V. et al. Nature Genet. 24, 13–14 (2000).
Skarnes, W.C. et al. Proc.Natl. Acad. Sci. U.S.A. 92, 6592–6596 (1995).
International Mouse Mutagenesis Consortium. Science 291, 1251–1255 (2001).
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Jackson, I. Mouse mutagenesis on target. Nat Genet 28, 198–200 (2001). https://doi.org/10.1038/90017
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DOI: https://doi.org/10.1038/90017
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