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Cortical reorganization in motor cortex after graft of both hands

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Abstract

Cortical organization shifts after sensory deprivation, but the reversibility of this reorganization has not been studied. Here, using functional magnetic resonance imaging (fMRI), we investigated the dynamics of cortical reorganization in a patient's motor cortex before and after bilateral hand transplantation. We found that amputation-induced cortical reorganization was reversed following hand transplantation.

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Figure 1: Activation maps in M1 obtained in the hand movement condition.
Figure 2: Activation maps in M1 obtained in the elbow movement condition.

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Acknowledgements

This work was supported by a CNRS grant to A.S.

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Authors and Affiliations

  1. Institute for Cognitive Science, CNRS, 67 Bd Pinel, Bron, 69675, France

    Pascal Giraux & Angela Sirigu

  2. Department of Physical Medicine, CHU, BD Pasteur, Saint-Etienne

    Pascal Giraux

  3. Radiology Department, CHU, BD Pasteur, Saint-Etienne

    Fabien Schneider

  4. Department of Surgical Transplant, E. Herriot Hospital, Place d'Arsonval, Lyon

    Jean-Michel Dubernard

Authors
  1. Pascal Giraux
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  2. Angela Sirigu
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  3. Fabien Schneider
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  4. Jean-Michel Dubernard
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Correspondence to Angela Sirigu.

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Giraux, P., Sirigu, A., Schneider, F. et al. Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci 4, 691–692 (2001). https://doi.org/10.1038/89472

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  • DOI: https://doi.org/10.1038/89472

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