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Brain glucosensing and the KATP channel

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An ATP-sensitive K+ channel in glucose-responsive neurons is shown to be required for the emergency response to severe glucose deprivation, but not necessarily for normal feeding.

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Figure 1: Proposed role of the ATP-sensitive K+ (KATP) channel on glucose-responsive (GR) neurons.

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Authors and Affiliations

  1. Neurology Service (127C), VA Medical Center, E. Orange, 07018, New Jersey, USA

    Barry E. Levin, Ambrose A. Dunn-Meynell & Vanessa H. Routh

  2. Departments of Neurosciences and Pharmacology and Physiology, New Jersey Medical School (UMDNJ), Newark, 07103, New Jersey, USA

    Barry E. Levin, Ambrose A. Dunn-Meynell & Vanessa H. Routh

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  1. Barry E. Levin
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  2. Ambrose A. Dunn-Meynell
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  3. Vanessa H. Routh
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Levin, B., Dunn-Meynell, A. & Routh, V. Brain glucosensing and the KATP channel. Nat Neurosci 4, 459–460 (2001). https://doi.org/10.1038/87405

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