Skip to main content

Advertisement

SpringerLink
Log in

A new latent HIV reservoir

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

The persistence of latently infected T cells is a major hurdle to eradication of HIV by antiviral therapy. It now seems that HIV latency can occur during normal T-cell differentiation in the thymus, and is regulated by the overall state of cellular gene transcription (pages 459–464).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: T cells bearing latent HIV provirus (▪—▪) can be generated during T cell maturation in the thymus.

References

  1. Chun, T.W. et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183–188 (1997).

    Article  CAS  Google Scholar 

  2. Finzi, D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Med. 5, 512–517 (1999).

    Article  CAS  Google Scholar 

  3. Pierson, T. et al. Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1. J. Virol. 74, 7824–7833 (2000).

    Article  CAS  Google Scholar 

  4. Brooks, D.G., Kitchen, S.G., Kitchen, C.M.R., Scripture-Adams, D.D. & Zack, J.A. Generation of HIV latency during thymopoiesis. Nature Med. 7, 459–464 (2001).

    Article  CAS  Google Scholar 

  5. Kitchen, S.G., Korin, Y.D., Roth, M.D., Landay, A. & Zack, J.A. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J. Virol. 72, 9054–9060 (1998).

    CAS  PubMed Central  Google Scholar 

  6. Papiernik, M. et al. Thymic abnormalities in fetuses aborted from human immunodeficiency virus type 1 seropositive women. Pediatrics 89, 297–301 (1992).

    CAS  Google Scholar 

  7. Persaud, D. et al. A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children. J. Clin. Invest. 105, 995–1003 (2000).

    Article  CAS  Google Scholar 

  8. Douek, D.C. et al. Changes in thymic output with age and during the treatment of HIV infection. Nature 396, 690–695 (1999).

    Article  Google Scholar 

  9. Jamieson, B.D. et al. Generation of functional thymocytes in the human adult. Immunity 10, 569–575 (1999).

    Article  CAS  Google Scholar 

  10. Haynes, B.F. et al. Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection. J. Clin. Invest . 103, 453–460 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine Division of Infectious Diseases The University of Texas Southwestern Medical Center, Dallas, Texas, USA

    Richard A. Koup

Authors
  1. Richard A. Koup
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koup, R. A new latent HIV reservoir. Nat Med 7, 404–405 (2001). https://doi.org/10.1038/86455

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/86455

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation