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Too many vessels? Not enough? The wrong kind? The VEGF debate continues.

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Although angiogenic factors provide hope for patients with ischemic diseases, a whirlwind of controversy surrounds their purported involvement in development of atherosclerosis (pages 425–429).

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Figure 1: Schematic diagram of the atherosclerotic plaque.

Bob Crimi

References

  1. Ware, J.A. & Simons, M. Angiogenesis in ischemic heart disease. Nature Med. 3, 158–164 (1997).

    Article  CAS  Google Scholar 

  2. Celletti, F. J. et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nature Med. 7, 425–429 (2001).

    Article  CAS  Google Scholar 

  3. Laham, R.J. et al. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized double blind placebo controlled trial. Circulation 100,1865–1871 (1999).

    Article  CAS  Google Scholar 

  4. Henry, T. et al. The VIVA trial: One year follow up (abstract). Circulation 102, II–309 (2000).

    Google Scholar 

  5. Post, M.J. & Ware J.A. Angiogenesis in atherosclerosis and restenosis. in Angiogenesis and Cardiovascular Disease (eds. Ware, J.A. & Simons, M.) 143–158. (Oxford University Press, New York, 1999)

    Google Scholar 

  6. Moulton, K. et al. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation 99, 1726–1732 (1999).

    Article  CAS  Google Scholar 

  7. Barger, A.C. et al. Hypothesis: vasa vasorum and neovascularization of human coronary arteries; a possible role in the pathophysiology of atherosclerosis. N. Engl. J. Med. 310, 175–177 (1984).

    Article  CAS  Google Scholar 

  8. Asahara, T. et al. Bone marrow derived endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circulation 85, 221–228 (1999).

    Article  CAS  Google Scholar 

  9. Simons, M. et al. Clinical trials in coronary angiogenesis: issues, problems, consensus. Circulation 102, e73–e78 (2000).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Molecular Pharmacology and Cardiology Albert Einstein College of Medicine Montefiore Medical Center Bronx, New York, USA

    J. Anthony Ware

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  1. J. Anthony Ware
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Ware, J. Too many vessels? Not enough? The wrong kind? The VEGF debate continues.. Nat Med 7, 403–404 (2001). https://doi.org/10.1038/86452

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