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Notchless T cell maturation?

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Notch is heavily involved in T cell lineage commitment . . . or is it? New data indicates that neither CD4 nor CD8 cell maturation is Notch1-dependent, whereas Notch1 is critical for earlier steps in T cell development.

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Figure 1: Notch effects defined by overexpression and by genetic disruption.

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Authors and Affiliations

  1. Division of Biology 156-29, California Institute of Technology, Pasadena, 91125, CA, USA

    Ellen V. Rothenberg

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  1. Ellen V. Rothenberg
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Rothenberg, E. Notchless T cell maturation?. Nat Immunol 2, 189–190 (2001). https://doi.org/10.1038/85231

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