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A fork in the road to fertility

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Haploinsufficiency of FOXL2, a new forkhead transcription factor, causes blepharophimosis/ptosis/epicanthus inversus syndrome (BPES), a rare developmental disorder affecting the eyelid and sometimes the ovary. A new study implicates FOXL2 as the first human gene required for the maintenance of ovarian follicles. The discovery of FOXL2 may provide insight into the causes of idiopathic premature ovarian failure, a disease that burdens many infertile couples.

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Figure 1: Transcript map of YAC 925B1.

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Authors and Affiliations

  1. McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, 75390, Texas, USA

    Robyn L Prueitt & Andrew R Zinn

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  1. Robyn L Prueitt
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  2. Andrew R Zinn
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Prueitt, R., Zinn, A. A fork in the road to fertility. Nat Genet 27, 132–134 (2001). https://doi.org/10.1038/84735

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