Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.
This is a preview of subscription content, log in via an institution to check access.
References
Mein, C.A. et al. Nature Genet. 19, 297–300 (1998).
Morahan, G. Nature Genet. 27, 218–221 (2001).
Gately, M.K. et al. Annu. Rev. Immunol. 16, 495–512 (1998).
Trinchieri, G. Annu. Rev. Immunol. 13, 251–276 (1995).
Atkinson, M.A. & Leiter, E.H. Naure Med. 5, 601–604 (1999).
Trembleau, S. et al. J. Exp. Med. 181, 817–821 (1995).
Trembleau, S. et al. J. Immunol. 165, 6748–6755 (2000).
Trembleau, S., Penna, G., Gregori, S., Gately, M.K. & Adorini, L. Eur. J. Immunol. 27, 2230–2239 (1997).
Rothe, H., O'Hara, R.M., Martin, S. & Kolb, H. Diabetologia 40, 641–646 (1997).
Trembleau, S. et al. J. Immunol. 163, 2960–2968 (1999).
Hultgren, B., Huang, X., Dybdal, N. & Stewart, T.A. Diabetes 45, 812–817 (1996).
Benoist, C. & Mathis, D. Cell 89, 1–3 (1997).
Szelachowska, M., Kretowski, A. & Kinalska, I. Horm. Metab. Res. 29, 168–171 (1997).
Adorini, L. et al. Chem. Immunol. 68, 175–197 (1997).
Oppmann, B. et al. Immunity 13, 715–725 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Adorini, L. Interleukin 12 and autoimmune diabetes. Nat Genet 27, 131–132 (2001). https://doi.org/10.1038/84732
Issue Date:
DOI: https://doi.org/10.1038/84732
- Springer Nature America, Inc.
This article is cited by
-
Elevated Levels of Serum IL-12 and IL-18 are Associated with Lower Frequencies of CD4+CD25highFOXP3+ Regulatory T cells in Young Patients with Type 1 Diabetes
Inflammation (2014)
-
Differential gene expression in pancreatic tissues of streptozocin-induced diabetic rats and genetically-diabetic mice in response to hypoglycemic dipeptide cyclo (His-Pro) treatment
Molecular Biology Reports (2012)
-
12/15‐Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3‐L1 Adipocytes
Obesity (2009)
-
New autoimmune genes and the pathogenesis of type 1 diabetes
Current Diabetes Reports (2004)
-
A TaqI polymorphism in the 3′UTR of the IL-12 p40 gene correlates with increased IL-12 secretion
Genes & Immunity (2002)