A population of stem cells that are capable of differentiating into endothelial and smooth muscle cells has been identified, offering improved prospects for vascular tissue engineering.
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Steve Horwitz
References
Darland, D.C. & D'Amore, P.A. Blood vessel maturation: vascular development comes of age. J. Clin. Invest. 103, 157–158 (1999)
Yamashita, J. et al. Embryonic stem cell-derived Flk1-positive cells serve as vascular progenitors. Nature 408, 92–96 (2000).
DeRuiter, M.C. et al. Embryonic endothelial cells transdifferentiate into mesenchymal cells expressing smooth muscle actins in vivo and in vitro. Circ. Res. 80, 444–451 (1997).
Borrione, A. et al. Nonmuscle and smooth muscle myosin isoforms in bovine endothelial cells. Exptl. Cell Res. 190, 1–10 (1990).
Shalaby, F. et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62–66 (1995).
Schuh, A.C., Faloon, P., Hu, Q.-L., Bhimani, M. & Choi, K. In vitro hematopoietic and endothelial potential of flk-1−/− embryonic stem cells and embryos. Proc. Natl. Acad. Sci. USA 96, 2159–2164 (1999).
Hirschi, K., Rohovsky, S.A. & D'Amore, P.A. PDGF, TGF-β and heterotypic cell-cell interactions mediate the recruitment and differentiation of 10T1/2 cells to a smooth muscle cell fate. J. Cell. Biol. 141,z 805–814 (1998).
Hirschi, K.K., Rohovsky, S.A., Beck, L.H., Smith, S.R. & D'Amore, P.A. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ. Res. (in the press).
Holycross, B.J., Blank, R.S., Thompson, M.M., Peach, M.J. & Owens, G.K. Platelet-derived growth factor-BB-induced suppression of smooth muscle cells differentiation. Circ. Res. 71, 1525–1532 (1992).
Lindahl, P., Johansson, B.R., Levéen, P. & Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277, 242–245 (1997).
Waldo, K.L., Kumiski, D.H. & Kirby, M.L. Association of the cardiac neural crest with development of the coronary arteries in the chick embryo. Anat. Rec. 239, 315–331 (1994).
Asahara, T. et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85, 221–228 (1999).
Grosskreutz, C.L., Anand-Apte, B., Terman, B., Quinn, T.P. & D'Amore, P.A. Vascular endothelial growth factor (VEGF) is a chemoattractant for vascular smooth muscle cells (SMC). Invest. Ophthalmol. Vis. Sci. 37, 5470 (1996).
Vacanti, J., Langer, R., Upton, J. & Marler, J. Transplantation of cells in matrices for tissue regeneration. Adv. Drug Deliv. Rev. 33, 165–182 (1998).
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D'Amore, P. Kissing Cousins—evidence for a common vascular cell precursor.. Nat Med 6, 1323–1324 (2000). https://doi.org/10.1038/82133
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DOI: https://doi.org/10.1038/82133
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