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Pointing (zinc) fingers at BRCA1 targets

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A long search for the mechanism by which BRCA1 regulates DNA damage-inducible genes leads to a novel zinc finger protein, ZBRK1.

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Figure 1: Activity of tumor suppressor BRCA1 in cellular DNA damage repair and transcription.

Bob Crimi

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Authors and Affiliations

  1. Department of Medicine, Genetics, and Pharmacology Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA

    Timothy K. MacLachlan & Wafik S. El-Deiry

Authors
  1. Timothy K. MacLachlan
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  2. Wafik S. El-Deiry
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MacLachlan, T., El-Deiry, W. Pointing (zinc) fingers at BRCA1 targets. Nat Med 6, 1318–1319 (2000). https://doi.org/10.1038/82119

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