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Immunomodulation: a new role for statins?

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Statins reduce the expression of the class II major histocompatibility complex (MHCII) by arterial cells, leading to a decreased T-cell response. This indicates that statins may be useful in treating graft atherosclerosis and other chronic inflammatory conditions. (pages 1399–1402)

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Figure 1: Statin modulation of the immune response.

Bob Crimi

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  1. Department of Medicine, 0682 University of California, San Diego 9500 Gilman Drive, MTF 110, La Jolla, 92093-0682, California

    Wulf Palinski

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  1. Wulf Palinski
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Palinski, W. Immunomodulation: a new role for statins?. Nat Med 6, 1311–1312 (2000). https://doi.org/10.1038/82107

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