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The challenges of in silico biology

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Moving from a reductionist paradigm to one that views cells as systems will necessitate changes in both the culture and the practice of research.

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Figure 1: The shift in emphasis of biological research.
Figure 2: Constraining possible behaviors.
Figure 3: Narrowing down the alternatives.
Figure 4

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Acknowledgements

I thank Markus Covert, Jeremy Edwards, David Letscher and Christophe Schilling for preparing the figures.

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  1. professor at the Department of Bioengineering, University of California–San Diego, La Jolla , 92093-0412, CA

    Bernhard Palsson

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Palsson, B. The challenges of in silico biology. Nat Biotechnol 18, 1147–1150 (2000). https://doi.org/10.1038/81125

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