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Achieving neuronal patterning by repression

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The diffusible signal Sonic Hedgehog (Shh) controls cell type specification in the ventral spinal cord. Litingtung and Chiang now show that some defects due to the lack of Shh are rescued by deleting the transcription factor Gli3, suggesting that Shh works by inactivating Gli3.

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Figure 1: The position and identity of six cell types in the ventral spinal cord of wild-type (WT) and mutant embryos may be determined by a homeodomain protein code under Shh and retinoid regulation (modified from ref. 2).
Figure 2: Hypothetical consequences for homeodomain protein expression and the resulting neuronal subtypes in wild-type and different mutant mice.

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Authors and Affiliations

  1. Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, 94080, California, USA

    Donna Stone & Arnon Rosenthal

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  1. Donna Stone
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  2. Arnon Rosenthal
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Stone, D., Rosenthal, A. Achieving neuronal patterning by repression. Nat Neurosci 3, 967–969 (2000). https://doi.org/10.1038/79894

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