The proto-oncogene BCL6 participates in the regulation of immune responses; a lack of it leads to generalized type 2 inflammation. Macrophage chemokine genes have now been identified as targets for BCL-6 repression and perhaps induce this inflammation.
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Canfield, S., Rothman, P. TH2 inflammation repressed by chemokines. Nat Immunol 1, 189–190 (2000). https://doi.org/10.1038/79720
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DOI: https://doi.org/10.1038/79720
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