Skip to main content
SpringerLink
Log in

Marriage, divorce, and promiscuity in human B cells

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

It is becoming more apparent that some B cells do not carry the same antigen receptors throughout their life. B cells that have edited their receptors have now been found in humans as rare cells that accumulate in arthritic joints.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Differences in H3CDR3 size and shape are illustrated in this comparison of four known antibody structures.

References

  1. Nemazee, D. A. & Weigert, M. G. J. Exp. Med. 191, 1813–1818 (2000).

    Article  CAS  Google Scholar 

  2. Melchers, F. Proc. Natl Acad. Sci., U.S A. 96, 2571– 2573 (1999).

    Article  CAS  Google Scholar 

  3. Kline, G. H. et al. J. Immunol. 161, 1608– 1618 (1998).

    CAS  PubMed  Google Scholar 

  4. Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E. & Kelsoe, G. Science 274, 2094– 2097 (1996).

    Article  CAS  Google Scholar 

  5. Yu, W. et al. Nature 400, 682–687 (1999).

    Article  CAS  Google Scholar 

  6. Meffre, E. et al. Nature Immunology 1, 207– 213 (2000).

    Article  CAS  Google Scholar 

  7. Kirkham, P. M. & Schroeder, H. W., Jr Semin. Immunol. 6, 347–360 ( 1994).

    Article  CAS  Google Scholar 

  8. Guelpa-Fonlupt, V. et al. Mol. Immunol. 31, 1099– 1108 (1994).

    Article  CAS  Google Scholar 

  9. Shiokawa, S. et al. J. Immunol. 162, 6060– 6070 (1999).

    CAS  PubMed  Google Scholar 

  10. Bridges, S.L., Jr. et al. J. Clin. Invest. 96, 831–841 (1995).

    Article  CAS  Google Scholar 

  11. Schettino, E. W., Chai, S. K., Kasaian, M. T., Schroeder, H. W., Jr & Casali, P. J. Immunol. 158, 2477–2489 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Alabama at Birmingham, Birmingham, 35294-3300, AL, USA

    Harry W. Schroeder Jr. & Perry M. Kirkham

  2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, 35294-3300, AL, USA

    Harry W. Schroeder Jr.

Authors
  1. Harry W. Schroeder Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Perry M. Kirkham
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schroeder, H., Kirkham, P. Marriage, divorce, and promiscuity in human B cells. Nat Immunol 1, 187–188 (2000). https://doi.org/10.1038/79717

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/79717

  • Springer Nature America, Inc.

Search

Navigation