Skip to main content
SpringerLink
Log in

CooA, CAP and allostery

  • News & Views
  • Published:

From Nature Structural Biology

View current issue Submit your manuscript

The crystal structure of the CooA protein yields potential insight into the general mechanism of allostery within the CAP family of transcriptional regulators.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Mechanisms of regulation by the CAP family of transcriptional regulators.
Figure 2: Structures of CAP proteins in different conformational states.

References

  1. Kerby, R.L., Ludden, P.W. & Roberts, G.P. J. Bacteriol. 177, 2241– 2244 (1995).

    Article  CAS  Google Scholar 

  2. Shelver, D., Kerby, R.L., He, Y. & Roberts, G.P. J. Bacteriol. 177, 2157–2163 ( 1995).

    Article  CAS  Google Scholar 

  3. He, Y., Shelver, D., Kerby, R.L. & Roberts, G.P. J. Biol. Chem. 271, 120–123 (1996).

    Article  CAS  Google Scholar 

  4. Aono, S., Nakajima, H., Saito, K. & Okada, M. Biochem. Biophys. Res. Commun. 228, 752–756 (1996).

    Article  CAS  Google Scholar 

  5. Shelver, D., Kerby, R.L., He, Y. & Roberts, G.P. Proc. Natl. Acad. Sci. USA 94, 11216–11220 (1997).

    Article  CAS  Google Scholar 

  6. Lanzilotta, W.N. et al. Nature Struct. Biol. 7, 876– 880 (2000).

    Article  CAS  Google Scholar 

  7. Schultz, S.C., Shields, G.C. & Steitz, T.A. Science 253, 1001– 1007 (1991).

    Article  CAS  Google Scholar 

  8. McKay, D.B. & Steitz, T.A. Nature (London) 290, 744–749 (1981).

    Article  CAS  Google Scholar 

  9. Kiley, P.J. & Beinert, H. FEMS Microbiol. Rev. 22, 341–352 ( 1998).

    Article  CAS  Google Scholar 

  10. Aono, S. & Nakajima, H. Coord. Chem. Rev. 192, 267–282 ( 1999).

    Article  Google Scholar 

  11. Perutz, M.F. Nature 228, 726–739 ( 1970).

    Article  CAS  Google Scholar 

  12. Gilles-Gonzalez, M.A., Ditta, G.S. & Helinski, D.R. Nature 350, 170 –172 (1991).

    Article  CAS  Google Scholar 

  13. Gong, W. et al. Proc. Natl. Acad. Sci. USA 95, 15177– 15182 (1998).

    Article  CAS  Google Scholar 

  14. Perutz, M.F. Mechanisms of cooperativity and allosteric regulation in proteins (Cambridge University Press, Cambridge, UK; 1989).

    Book  Google Scholar 

  15. Gong, W., Hao, B. & Chan, M.K. Biochemistry 39, 3955– 3962 (2000).

    Article  CAS  Google Scholar 

  16. Aono, S., Ohkubo, K., Matsuo, T. & Nakajima, H. J. Biol. Chem. 273, 25757–25764 ( 1998).

    Article  CAS  Google Scholar 

  17. Shelver, D. et al. Biochemistry 38, 2669– 2678 (1999).

    Article  CAS  Google Scholar 

  18. Dhawan, I.K., Shelver, D., Thorsteinsson, M.V., Roberts, G.P. & Johnson, M.K. Biochemistry 38, 12805–12813 (1999).

    Article  CAS  Google Scholar 

  19. Reynolds, M.F. et al. J. Am. Chem. Soc. 120, 9080– 9081 (1998).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I would like to thank W. Lanzilotta and T. Poulos for access to the atomic coordinates.

Author information

Authors and Affiliations

  1. the Departments of Chemistry and Biochemistry, The Ohio State University, 484 West 12 th Avenue, Columbus, 43210 , Ohio, USA

    Michael K. Chan

Authors
  1. Michael K. Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chan, M. CooA, CAP and allostery. Nat Struct Mol Biol 7, 822–824 (2000). https://doi.org/10.1038/79559

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/79559

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation