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Hierarchical folding of cytochrome c

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Formation of secondary structure during protein folding can now be probed on the submillisecond time scale. By monitoring the formation of α-helix formation during the initial collapse of cytochrome c, its folding mechanism is delineated.

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Acknowledgements

We thank E. Stellwagen of the University of Iowa for helpful discussions. This work was supported by a grant from the National Institutes of Health.

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Authors and Affiliations

  1. the Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, Resnick Campus, 1300 Morris Park Avenue, Bronx, 10461, New York, USA

    Syun-Ru Yeh & Denis L. Rousseau

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  1. Syun-Ru Yeh
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  2. Denis L. Rousseau
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Correspondence to Denis L. Rousseau.

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Yeh, SR., Rousseau, D. Hierarchical folding of cytochrome c. Nat Struct Mol Biol 7, 443–445 (2000). https://doi.org/10.1038/75831

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