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Preassembly and transport of nerve terminals: a new concept of axonal transport

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A morphological study suggests a new view of synapse formation by demonstrating that presynaptic elements are assembled into ‘prototerminals’ before being transported down axons by fast, saltatory movement. These structures stop moving when the axon contacts a dendrite.

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Figure 1: Transport of prefabricated prototerminals.
Figure 2: Synaptic vesicle formation along axons and at synaptic contacts.

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Authors and Affiliations

  1. Department of Biophysics and Biochemistry, University of California, San Francisco, 94143-0448, California, USA

    Jack Roos & Regis B. Kelly

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  1. Jack Roos
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  2. Regis B. Kelly
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Roos, J., Kelly, R. Preassembly and transport of nerve terminals: a new concept of axonal transport. Nat Neurosci 3, 415–417 (2000). https://doi.org/10.1038/74773

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