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Fly meets shotgun: shotgun wins

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The sequencing group at Celera Genomics Corporation has cooperated with the European, Canadian and American genome projects to demonstrate that a genomic sequence as large as that of Drosophila melanogaster euchromatin (120 Mb) can be obtained by assembling the sequence of random (‘shotgun’) clones without the prerequisite for a clone-based physical map.

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Figure 1: Mosaic fly with one vestigial wing found by Calvin Bridges on 6 August 1923, and drawn by Edith M. Wallace.
Figure 2: In situ hybridization of a P1 clone with a site in a polytene salivary-gland chromosome.

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  1. Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge , 02138, Massachusetts, USA

    Daniel L Hartl

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  1. Daniel L Hartl
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Hartl, D. Fly meets shotgun: shotgun wins. Nat Genet 24, 327–328 (2000). https://doi.org/10.1038/74125

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