The mechanism by which cells recognize misfolded proteins in the endoplasmic reticulum has been defined at the cell biological level. The enzyme UDP-glucose:glycoprotein glucosyltransferase identifies and specifically glucosylates misfolded domains within a multi-domain protein.
References
Ritter, C. & Helenius, A. Nature Struct. Biol. 7, 278–280 (2000).
Ellgaard, L., Molinari, M. & Helenius, A. Science 286, 1882– 1888 (1999).
Helenius, A., Trombetta, E.S., Hebert, D.N. & Simons, J.F. Trends Cell. Biol. 7, 193–200 (1997).
Hebert, D.N., Foellmer, B. & Helenius, A. EMBO J. 15, 2961– 2968 (1996).
Vassilakos, A., Cohen-Doyle, M.F., Peterson, P.A., Jackson, M.R. & Williams, D.B. EMBO J. 15, 1495–1506 (1996).
Zapun, A. et al. J. Biol. Chem. 273, 6009– 6012 (1998).
Rodan, A.R., Simons, J.F., Trombetta, E.S. & Helenius, A. EMBO J. 15, 6921–6930 ( 1996).
Zapun, A. et al. Cell 88, 29–38 (1997).
Ganan, S., Cazzulo, J.J. & Parodi, A.J. Biochemistry 30, 3098– 3104 (1991).
Plemper, R.K. & Wolf, D.H. Trends Biochem. Sci. 24, 266–270 (1999).
Sousa, M.C., Ferrero-Garcia, M.A. & Parodi, A.J. Biochemistry 31, 97– 105 (1992).
Sousa, M. & Parodi, A.J. EMBO. J. 14, 4196–4203 (1995).
Fernandez, F., D'Alessio, C., Fanchiotti, S. & Parodi, A.J. EMBO J. 17, 5877–5886 ( 1998).
Horwich, A.L., Weber-Ban, E.U. & Finley, D. Proc. Natl. Acad. Sci. U.S.A. 96, 11033–11040 (1999).
Larsen, C.N. & Finley, D. Cell 91, 431 –434 (1997).
Baumeister, W., Walz, J., Zühl, F. & Seemüller, E. Cell 92, 367–380 (1998).
Bukau, B. & Horwich, A.L. Cell 92, 351–366 (1998).
Lowe, J. et al. Science 268, 533–539 (1995).
Groll, M. et al. Nature 386, 463–471 (1997).
Wang, J., Hartling, J.A. & Flanagan, J.M. Cell 91, 447– 456 (1997).
Goldberg, A. L. Science 268, 522–524 ( 1995).
Braig, K. et al. Nature 371, 578–586 (1994).
Xu, Z., Horwich, A.L. & Sigler, P.B. Nature 388, 741– 750 (1997).
Fenton, W.A., Kashi, Y., Furtak, K. & Horwich, A.L. Nature 371, 614–619 (1994).
Buckle, A.M., Zahn, R. & Fersht, A.R. Proc. Natl. Acad. Sci. U.S.A. 94, 3571–3575 (1997).
Hlodan, R., Tempst, P. & Hartl, F.U. Nature Struct. Biol. 2, 587– 595 (1995).
Itzhaki, L.S., Otzen, D.E. & Fersht, A.R. Biochemistry 34, 14581– 14587 (1995).
Zhu, X. et al. Science 272, 1606–1614 (1996).
Wang, H. et al. Biochemistry 37, 7929– 7940 (1998).
Rudiger, S., Germeroth, L., Schneider-Mergener, J. & Bukau, B. EMBO J. 16, 1501–1517 ( 1997).
Blond-Elguindi, S. et al. Cell 75, 717–728 (1993).
Flynn, G.C., Chappell, T.G. & Rothman, J.E. Science 245, 385– 390 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Matouschek, A. Recognizing misfolded proteins in the endoplasmic reticulum. Nat Struct Mol Biol 7, 265–266 (2000). https://doi.org/10.1038/74012
Issue Date:
DOI: https://doi.org/10.1038/74012
- Springer Nature America, Inc.