The U1A protein regulates the activity of poly(A) polymerase by interacting with an RNA element in the 3′ untranslated region of its mRNA. The structure of the trimolecular complex made up of two U1A molecules bound to the target RNA explains the cooperative regulation in this system.
References
Varani, G. & Nagai, K. Ann. Rev. Biophys. Biomol. Struct. 27, 407–445 ( 1998).
Boelens, W.C. et al. Cell 72, 881–892 (1993).
Van Gelder, C. W. G. et al. EMBO J. 12, 5191–5200 (1993).
Gunderson, S. I. et al. Cell 76, 531–541 (1994).
Varani, L., Gunderson, S. I., Mattaj, I. W., Kay, L., Neuhaus, D., Varani, G. Nature Struct. Biol. 7, 329–335 (2000).
Nagai, K. Oubridge, C., Jessen, T.H., Li, J. & Evans, P.R. Nature 348, 515–520 (1990).
Oubridge, C., Ito, N., Evans, P. R. Teo, C.-H. & Nagai, K. Nature 372, 432– 438 (1994).
Allain, F.H.T. et al. Nature 280, 646–650 (1996).
Gunderson, S.I., Vagner, S., Polycarpou-Schwartz, M. & Mattaj, I.W. Genes & Dev. 11, 761–773 (1997).
Zwahlen, C. et al. J. Am. Chem. Soc 119, 6711– 6721 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Puglisi, J. mRNA processing: The 3′-end justifies the means. Nat Struct Mol Biol 7, 263–264 (2000). https://doi.org/10.1038/74008
Issue Date:
DOI: https://doi.org/10.1038/74008
- Springer Nature America, Inc.