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The envelope, please: Nuclear lamins and disease

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Abstract

Naturally occurring mutations within the LMNA gene, which encodes nuclear lamin, have been identified in patients with three rare and apparently unrelated diseases. Understanding how these mutations cause disease will improve our knowledge of nuclear envelope function, as well as the pathogenesis of myopathy, cardiac conduction abnormalities and drug-induced lipodystrophy.

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Figure 1: The nuclear membranes include the interconnected but distinct inner and outer nuclear membranes and the nuclear pore membrane.

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Authors and Affiliations

  1. Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada

    Robert A. Hegele

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  1. Robert A. Hegele
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Hegele, R. The envelope, please: Nuclear lamins and disease. Nat Med 6, 136–137 (2000). https://doi.org/10.1038/72221

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