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The food of sweet and bitter fancy

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Abstract

The MAP30 ribosomal inactivating protein structure has been determined by NMR spectroscopy. This anti-HIV and anti-cancer protein is an RNA and DNA glycosylase as well as a DNA apurinic/apyrimidinic (AP) lyase.

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Figure 1: Stereo view of the MAP30 fold, omitting the disordered C-terminus, and adenine binding site.

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Authors and Affiliations

  1. the Department of Molecular Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, MB 4, 10550 North Torrey Pines Rd. , La Jolla, 92037, California, USA

    Christopher D. Putnam & John A. Tainer

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  1. Christopher D. Putnam
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  2. John A. Tainer
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Correspondence to John A. Tainer.

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Putnam, C., Tainer, J. The food of sweet and bitter fancy. Nat Struct Mol Biol 7, 17–18 (2000). https://doi.org/10.1038/71211

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