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Exiting an RNA world

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Abstract

The RNA world hypothesis gains support from the in vitro evolution of a bifunctional ribozyme that can recognize an activated glutaminyl ester and subsequently aminoacylate a tRNA molecule.

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Figure 1: Schematic illustration of the reactions catalyzed by aminoacylating ribozymes.
Figure 2: Possible transition out of the RNA world.

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Authors and Affiliations

  1. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, 10550 North Torrey Pines Road, La Jolla, 92037, California, USA

    Paul Schimmel & Shana O. Kelley

Authors
  1. Paul Schimmel
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  2. Shana O. Kelley
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Correspondence to Paul Schimmel.

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Schimmel, P., Kelley, S. Exiting an RNA world. Nat Struct Mol Biol 7, 5–7 (2000). https://doi.org/10.1038/71194

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