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SMAD destruction turns off signalling

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Abstract

SMAD proteins are key signal-transduction molecules whose activity must be tightly regulated. SMADs can be activated by phosphorylation, and at least one, Smad2, can be deactivated by degradation by protein-crunching proteasomes in the nucleus.

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Figure 1: Model for ubiquitin-mediated control of the transforming growth factor-β (TGF-β)/SMAD pathway.

References

  1. Lo, R. S. & Massagué,J. Nature Cell Biol. 1, 472–478 (1999).

    Article  CAS  Google Scholar 

  2. Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L. & Thomsen, G. H. Nature 400, 687–693 (1999).

    Article  CAS  Google Scholar 

  3. Piek, E., Heldin, C.-H. & ten Dijke, P. FASEB J. (in the press).

  4. Ciechanover, A. EMBO J. 17, 7151–7160 (1998).

    Article  CAS  Google Scholar 

  5. Laney, J. D. & Hochstrasser, M. Cell 97, 427–430 (1999).

    Article  CAS  Google Scholar 

  6. Sun, Y., Liu, X., Ng-Eaton, E., Lodish, H. F. & Weinberg, R. A. Proc. Natl Acad. Sci. USA 96, 12442–12447 (1999).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Box 595, Uppsala, S-751 24, Sweden

    Carl-Henrik Heldin

  2. Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands

    Peter ten Dijke

Authors
  1. Carl-Henrik Heldin
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  2. Peter ten Dijke
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Correspondence to Peter ten Dijke.

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Heldin, CH., ten Dijke, P. SMAD destruction turns off signalling. Nat Cell Biol 1, E195–E197 (1999). https://doi.org/10.1038/70223

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