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Neurodegenerative disorders

Neural synchronization in Alzheimer's disease

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Electrical oscillations generated by neural circuits are disrupted in Alzheimer's disease. Restoring these oscillations in mouse models activates immune cells to clear disease-associated amyloid-β protein from the brain. See Article p.230

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Figure 1: Gamma oscillations stimulate the clearance of amyloid-β protein deposits.

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References

  1. Wang, X.-J. Physiol. Rev. 90, 1195–1268 (2010).

    Article  Google Scholar 

  2. Uhlhaas, P. J. & Singer, W. Neuron 52, 155–168 (2006).

    Article  CAS  Google Scholar 

  3. Iaccarino, H. F. et al. Nature 540, 230–235 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Koenig, T. et al. Neurobiol. Aging 26, 165–171 (2005).

    Article  CAS  Google Scholar 

  5. Pijnenburg, Y. A. L. et al. Clin. Neurophysiol. 115, 1332–1339 (2004).

    Article  CAS  Google Scholar 

  6. Palop, J. J. et al. Neuron 55, 697–711 (2007).

    Article  CAS  Google Scholar 

  7. Verret, L. et al. Cell 149, 708–721 (2012).

    Article  CAS  Google Scholar 

  8. Gillespie, A. K. et al. Neuron 90, 740–751 (2016).

    Article  CAS  Google Scholar 

  9. Sohal, V. S., Zhang, F., Yizhar, O. & Deisseroth, K. Nature 459, 698–702 (2009).

    Article  ADS  CAS  Google Scholar 

  10. Fries, P., Nikolić, D. & Singer, W. Trends Neurosci. 30, 309–316 (2007).

    Article  CAS  Google Scholar 

  11. Palop, J. J. & Mucke, L. Nature Neurosci. 13, 812–818 (2010).

    Article  CAS  Google Scholar 

  12. Cirrito, J. R. et al. Neuron 48, 913–922 (2005).

    Article  CAS  Google Scholar 

  13. Brettschneider, J., Del Tredici, K., Lee, V. M.-Y. & Trojanowski, J. Q. Nature Rev. Neurosci. 16, 109–120 (2015).

    Article  CAS  Google Scholar 

  14. Pooler, A. M. et al. Alzheimers Res. Ther. 5, 49 (2013).

    Article  Google Scholar 

  15. Yankner, B. A., Lu, T. & Loerch, P. Annu. Rev. Pathol. 3, 41–66 (2008).

    Article  CAS  Google Scholar 

  16. Hong, S., Dissing-Olesen, L. & Stevens, B. Curr. Opin. Neurobiol. 36, 128–134 (2015).

    Article  Google Scholar 

  17. Hong, S. et al. Science 352, 712–716 (2016).

    Article  ADS  CAS  Google Scholar 

  18. Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M. & Davidson, R. J. Proc. Natl Acad. Sci. USA 101, 16369–16373 (2004).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Liviu Aron and Bruce A. Yankner are in the Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.,

    Liviu Aron & Bruce A. Yankner

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  1. Liviu Aron
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  2. Bruce A. Yankner
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Correspondence to Bruce A. Yankner.

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Aron, L., Yankner, B. Neural synchronization in Alzheimer's disease. Nature 540, 207–208 (2016). https://doi.org/10.1038/540207a

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