The presence of an N1 methyl group on adenine bases in DNA and RNA was thought to be a form of damage. Results now show that it also occurs at specific sites in messenger RNAs, where it affects protein expression. See Article p.441
This is a preview of subscription content, log in via an institution to check access.
Notes
References
Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).
Fu, Y., Dominissini, D., Rechavi, G. & He, C. Nature Rev. Genet. 15, 293–306 (2014).
Edelheit, S., Schwartz, S., Mumbach, M. R., Wurtzel, O. & Sorek, R. PLoS Genet. 9, e1003602 (2013).
Dominissini, D. et al. Nature 530, 441–446 (2016).
Mishima, E. et al. J. Am. Soc. Nephrol. 25, 2316–2326 (2014).
Helm, M., Giegé, R. & Florentz, C. Biochemistry 38, 13338–13346 (1999).
He, C. et al. Mol. Cell 20, 117–129 (2005).
Macon, J. B. & Wolfenden, R. Biochemistry 7, 3453–3458 (1968).
Singer, B. & Grunberger, D. Molecular Biology of Mutagens and Carcinogens (Plenum, 1983).
Aas, P. A. et al. Nature 421, 859–863 (2003).
Li, X. et al. Nature Chem. Biol. http://dx.doi.org/10.1038/nchembio.2040 (2016).
Author information
Authors and Affiliations
Corresponding authors
Related links
Related links
Related links in Nature Research
Molecular biology: RNA modification does a regulatory two-step
Rights and permissions
About this article
Cite this article
Kietrys, A., Kool, E. A new methyl mark on messengers. Nature 530, 423–424 (2016). https://doi.org/10.1038/530423a
Published:
Issue Date:
DOI: https://doi.org/10.1038/530423a
- Springer Nature Limited
This article is cited by
-
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer
Molecular Cancer (2021)
-
RNA modifications: what have we learned and where are we headed?
Nature Reviews Genetics (2016)