The polymerase enzyme from avian influenza A viruses does not function well in human cells. The protein ANP32A has been identified as the cellular factor mediating a major component of this host restriction. See Letter p.101
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Lowen, A. Host protein clips bird flu's wings in mammals. Nature 529, 30–31 (2016). https://doi.org/10.1038/529030a
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DOI: https://doi.org/10.1038/529030a
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