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A dendritic-cell brake on antitumour immunity

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Activation of a cellular stress response and the transcription factor XBP1 in dendritic cells has now been shown to limit the cells' ability to stimulate antitumour immune responses in a mouse model of ovarian cancer.

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Figure 1: XBP1 activation inhibits presentation of tumour antigens.

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Authors and Affiliations

  1. Oncological Science Department, Miriam Merad and Hélène Salmon are at the Tisch Cancer and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.,

    Miriam Merad & Hélène Salmon

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  1. Miriam Merad
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  2. Hélène Salmon
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Correspondence to Miriam Merad.

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Merad, M., Salmon, H. A dendritic-cell brake on antitumour immunity. Nature 523, 294–295 (2015). https://doi.org/10.1038/523294a

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