Bacterial infections during pregnancy can cause fetal death. The identification of a cell-signalling pathway induced during infection that recruits dangerous immune cells to the placenta may open up avenues to prevent this.
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References
Chaturvedi, V. et al. J. Clin. Invest. 125, 1713–1725 (2015).
Erlebacher, A. Annu. Rev. Immunol. 31, 387–411 (2013).
Lamont, R. F. et al. J. Perinat. Med. 39, 227–236 (2011).
Portnoy, D. A. Mol. Biol. Cell 23, 1141–1145 (2012).
Nancy, P. et al. Science 336, 1317–1321 (2012).
Wegorzewska, M. et al. J. Immunol. 192, 1938–1945 (2014).
Auerbuch, V., Lenz, L. L. & Portnoy, D. A. Infect. Immun. 69, 5953–5957 (2001).
Le Monnier, A. et al. Infect. Immun. 75, 950–957 (2007).
Robbins, J. R. & Bakardjiev, A. I. Curr. Opin. Microbiol. 15, 36–43 (2012).
Van Raemdonck, K., Van den Steen, P. E., Liekens, S., Van Damme, J. & Struyf, S. Cytokine Growth Factor Rev. http://dx.doi.org/10.1016/j.cytogfr.2014.11.009 (2014).
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Bakardjiev, A. Stillbirth prevented by signal blockade. Nature 520, 627–628 (2015). https://doi.org/10.1038/520627a
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DOI: https://doi.org/10.1038/520627a
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