The m6A structural modification of RNA regulates gene expression. It has now been found to mediate an unusual control mechanism: by altering the structure of RNA, m6A allows a regulatory protein to bind to that RNA. See Letter p.560
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References
Liu, N. et al. Nature 518, 560–564 (2015).
Perry, R. P. & Kelley, D. E. Cell 1, 37–42 (1974).
Desrosiers, R., Friderici, K. & Rottman, F. Proc. Natl Acad. Sci. USA 71, 3971–3975 (1974).
Fu, Y., Dominissini, D., Rechavi, G. & He, C. Nature Rev. Genet. 15, 293–306 (2014).
Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).
Lee, M., Kim, B. & Kim, V. N. Cell 158, 980–987 (2014).
Theler, D., Dominguez, C., Blatter, M., Boudet, J. & Allain, F. H.-T. Nucleic Acids Res. 42, 13911–13919 (2014).
Dethoff, E. A., Chugh, J., Mustoe, A. M. & Al-Hashimi, H. M. Nature 482, 322–330 (2012).
Liu, N. et al. RNA 19, 1848–1856 (2013).
Cieniková, Z., Damberger, F. F., Hall, J., Allain, F. H.-T. & Maris, C. J. Am. Chem. Soc. 136, 14536–14544 (2014).
Roost, C. et al. J. Am. Chem. Soc. 137, 2107–2115 (2015).
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Theler, D., Allain, FT. RNA modification does a regulatory two-step. Nature 518, 492–493 (2015). https://doi.org/10.1038/518492a
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DOI: https://doi.org/10.1038/518492a
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