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CRISPR engineering turns on genes

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The repurposing of a bacterial defence system known as CRISPR into a potent activator of gene expression in human cells enables powerful studies of gene function, as exemplified in cancer cells. See Article p.583

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Figure 1: RNAs as modular scaffolds for gene regulation.

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Authors and Affiliations

  1. Seung Woo Cho and Howard Y. Chang are in the Program in Epithelial Biology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.,

    Seung Woo Cho & Howard Y. Chang

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  1. Seung Woo Cho
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  2. Howard Y. Chang
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Correspondence to Howard Y. Chang.

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Cho, S., Chang, H. CRISPR engineering turns on genes. Nature 517, 560–562 (2015). https://doi.org/10.1038/517560a

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