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Toehold gene switches make big footprints

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The development of RNA-based devices called toehold switches that regulate translation might usher in an era in which protein production can be linked to almost any RNA input and provide precise, low-cost diagnostics.

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Figure 1: The design of toehold switches.

References

  1. Peralta-Yahya, P. P., Zhang, F., del Cardayre, S. B. & Keasling, J. D. Nature 488, 320–328 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Paddon, C. J. et al. Nature 496, 528–532 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Kemmer, C. et al. Nature Biotechnol. 28, 355–360 (2010).

    Article  CAS  Google Scholar 

  4. Rössger, K., Charpin-El-Hamri, G. & Fussenegger, M. Nature Commun. 4, 2825; http://dx.doi.org/10.1038/ncomms3825 (2013).

    Article  ADS  Google Scholar 

  5. Ausländer, D. et al. Mol. Cell 55, 397–408 (2014).

    Article  Google Scholar 

  6. Green, A. A., Silver, P. A., Collins, J. J. & Yin, P. Cell 159, 925–939 (2014).

    Article  CAS  Google Scholar 

  7. Ausländer, S. et al. Nature Methods 11, 1154–1160 (2014).

    Article  Google Scholar 

  8. Pardee, K. et al. Cell 159, 940–954 (2014).

    Article  CAS  Google Scholar 

  9. Xie, Z., Wroblewska, L., Prochazka, L., Weiss, R. & Benenson, Y. Science 333, 1307–1311 (2011).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Martin Fussenegger.

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Ausländer, S., Fussenegger, M. Toehold gene switches make big footprints. Nature 516, 333–334 (2014). https://doi.org/10.1038/516333a

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