Five papers extend the list of cancers that respond to therapies that restore antitumour immunity by blocking the PD-1 pathway, and characterize those patients who respond best. See Letters p.558, p.563, p.568, p.572 & p.577
References
Coley, W. B. Proc. R. Soc. Med. 3, 1–48 (1910).
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J. & Schreiber, R. D. Nature Immunol. 3, 991–998 (2002).
Koebel, C. M. et al. Nature 450, 903–907 (2007).
Shankaran, V. et al. Nature 410, 1107–1111 (2001).
Powles, T. et al. Nature 515, 558–562 (2014).
Herbst, R. S. et al. Nature 515, 563–567 (2014).
Tumeh, P. C. et al. Nature 515, 568–571 (2014).
Yadav, M. et al. Nature 515, 572–576 (2014).
Gubin, M. M. et al. Nature 515, 577–581 (2014).
Page, D. B., Postow, M. A., Callahan, M. K., Allison, J. P. & Wolchok, J. D. Annu. Rev. Med. 65, 185–202 (2014).
Robert, C. et al. Lancet 384, 1109–1117 (2014).
Topalian, S. L. et al. J. Clin. Oncol. 32, 1020–1030 (2014).
Wolchok, J. D. et al. Ann. Oncol. 24, 2174–2180 (2013).
Brahmer, J. R. et al. N. Engl. J. Med. 366, 2455–2465 (2012).
Topalian, S. L. et al. N. Engl. J. Med. 366, 2443–2454 (2012).
Hamid, O. et al. N. Engl. J. Med. 369, 134–144 (2013).
Taube, J. M. et al. Sci. Transl. Med. 4, 127ra37 (2012).
Brahmer, J. R. et al. J. Clin. Oncol. 28, 3167–3175 (2010).
Matsushita, H. et al. Nature 482, 400–404 (2012).
Duan, F. et al. J. Exp. Med. 211, 2231–2248 (2014).
Snyder, A. et al. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1406498 (2014).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wolchok, J., Chan, T. Antitumour immunity gets a boost. Nature 515, 496–498 (2014). https://doi.org/10.1038/515496a
Published:
Issue Date:
DOI: https://doi.org/10.1038/515496a
- Springer Nature Limited
This article is cited by
-
Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells
BMC Nutrition (2024)
-
A promising Prognostic risk model for advanced renal cell carcinoma (RCC) with immune-related genes
BMC Cancer (2022)
-
Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer
Nature Cancer (2021)
-
The Adaptive and Innate Immune Cell Landscape of Uterine Leiomyosarcomas
Scientific Reports (2020)
-
The hypoxic tumour microenvironment
Oncogenesis (2018)