The identification of the enzyme plasmin as a defence against cancer cells that have spread to the brain, and of tumour-cell serpin proteins that inhibit plasmin production, outlines a mechanism for the formation of brain metastases.
References
Sporn, M. B. Lancet 347, 1377–1381 (1996).
Maher, E. A., Mietz, J., Arteaga, C. L., DePinho, R. A. & Mohla, S. Cancer Res. 69, 6015–6020 (2009).
Mehlen, P. & Puisieux, A. Nature Rev. Cancer 6, 449–458 (2006).
Valiente, M. et al. Cell 156, 1002–1016 (2014).
Heyn, C. et al. Magn. Reson. Med. 56, 1001–1010 (2006).
Kienast, Y. et al. Nature Med. 16, 116–122 (2010).
Croucher, D. R., Saunders, D. N., Lobov, S. & Ranson, M. Nature Rev. Cancer 8, 535–545 (2008).
Bao, S. et al. Cancer Res. 68, 6043–6048 (2008).
Felding-Habermann, B. et al. J. Cell Biol. 139, 1567–1581 (1997).
Erler, J. T. & Linding, R. J. Pathol. 220, 290–296 (2010).
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Erler, J. Disabling defences in the brain. Nature 508, 46–47 (2014). https://doi.org/10.1038/508046a
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DOI: https://doi.org/10.1038/508046a
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