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Immunology

Oiling the wheels of autoimmunity

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Oily substances in the skin have now been shown to contain structures that activate a population of skin-homing, self-reactive T cells. The responses of these immune cells may contribute to local defences, but also to autoimmune disease.

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Figure 1: Skin-antigen recognition by self-reactive T cells.

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Correspondence to Mitchell Kronenberg or Wendy L. Havran.

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Kronenberg, M., Havran, W. Oiling the wheels of autoimmunity. Nature 506, 42–43 (2014). https://doi.org/10.1038/506042a

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