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Molecular biology

Antibiotic re-frames decoding

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Ketolide antibiotics have been found to induce a ribosomal frameshift — a change in the way that RNA is translated — in bacteria. This promotes the expression of a gene for antibiotic resistance, and may have broader implications.

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Figure 1: Antibiotic-induced frameshifting.

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Authors and Affiliations

  1. John F. Atkins and Pavel V. Baranov are in the School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.,

    John F. Atkins & Pavel V. Baranov

  2. J.F.A. is also in the Department of Human Genetics, University of Utah, Salt Lake City, USA.,

    John F. Atkins

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  1. John F. Atkins
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  2. Pavel V. Baranov
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Correspondence to John F. Atkins or Pavel V. Baranov.

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Atkins, J., Baranov, P. Antibiotic re-frames decoding. Nature 503, 478–479 (2013). https://doi.org/10.1038/503478a

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