Ketolide antibiotics have been found to induce a ribosomal frameshift — a change in the way that RNA is translated — in bacteria. This promotes the expression of a gene for antibiotic resistance, and may have broader implications.
References
Gupta, P., Kannan, K., Mankin, A. S. & Vázquez-Laslop, N. Mol. Cell http://dx.doi.org/10.1016/j.molcel.2013.10.013 (2013).
Horinouchi, S. & Weisblum, B. Proc. Natl Acad. Sci. USA 77, 7079–7083 (1980).
Shivakumar, A. G. et al. Proc. Natl Acad. Sci. USA 77, 3903–3907 (1980).
Vázquez-Laslop, N. et al. Mol. Cell 30, 190–202 (2008).
Craigen, W. J. & Caskey, C. T. Nature 322, 273–275 (1986).
Matsufuji, S. et al. Cell 80, 51–60 (1995).
Ingolia, N. T. et al. Science 324, 218–223 (2009).
Ivanov, I. P. et al. Nucleic Acids Res. 38, 353–359 (2010).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Atkins, J., Baranov, P. Antibiotic re-frames decoding. Nature 503, 478–479 (2013). https://doi.org/10.1038/503478a
Published:
Issue Date:
DOI: https://doi.org/10.1038/503478a
- Springer Nature Limited
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.