A genome-wide analysis of DNA and RNA sequences, gene expression and DNA modifications in 200 samples of acute myeloid leukaemia sets the stage for data integration and verification that will enhance our understanding of this cancer.
References
The Cancer Genome Atlas Research Network . N. Engl. J. Med. 368, 2059–2074 (2013).
Lin, C. Y. et al. Cell 151, 56–67 (2012).
Eppert, K. et al. Nature Med. 17, 1086–1093 (2011).
Ding, L. et al. Nature 481, 506–509 (2012).
Huang, F. W. et al. Science 339, 957–959 (2013).
Gerstein, M. B. et al. Nature 489, 91–100 (2012).
Patel, J. P. et al. N. Engl. J. Med. 366, 1079–1089 (2012).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Aerts, S., Cools, J. Mutations close in on gene regulation. Nature 499, 35–36 (2013). https://doi.org/10.1038/499035a
Published:
Issue Date:
DOI: https://doi.org/10.1038/499035a
- Springer Nature Limited
This article is cited by
-
Nuclear receptors connect progenitor transcription factors to cell cycle control
Scientific Reports (2017)
-
Sequence search and analysis of gene products containing RNA recognition motifs in the human genome
BMC Genomics (2014)
-
Putative cis-regulatory drivers in colorectal cancer
Nature (2014)