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Oxidation controls the DUB step

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Reversible oxidation of amino-acid residues can directly regulate the activity of cellular enzymes. This principle has now been extended to deubiquitinating enzymes, with implications for cell signalling and protein turnover.

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Figure 1: Redox regulation of deubiquitinating enzymes (DUBs).

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  1. Michael J. Clague is in the Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool L69 3BX, UK.,

    Michael J. Clague

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  1. Michael J. Clague
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Correspondence to Michael J. Clague.

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Clague, M. Oxidation controls the DUB step. Nature 497, 49–50 (2013). https://doi.org/10.1038/497049a

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