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Biochemistry

Sirtuin on a high-fat diet

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It emerges that the sirtuin enzyme SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α. See Letter p.110

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Figure 1: Protein deacylation.

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Authors and Affiliations

  1. Poonam Bheda is at the Institut Génétique et de Biologie Moleculaire et Cellulaire, Illkirch 67404, France.,

    Poonam Bheda

  2. Cynthia Wolberger is in the Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.,

    Cynthia Wolberger

Authors
  1. Poonam Bheda
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  2. Cynthia Wolberger
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Correspondence to Cynthia Wolberger.

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Bheda, P., Wolberger, C. Sirtuin on a high-fat diet. Nature 496, 41–42 (2013). https://doi.org/10.1038/496041a

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