Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.
This is a preview of subscription content, log in via an institution to check access.
References
Dang, L. et al. Nature 462, 739–744 (2009).
Ward, P. S. et al. Cancer Cell 17, 225–234 (2010).
Losman, J. A. et al. Science http://dx.doi.org/10.1126/science.1231677 (2013).
Parsons, D. W. et al. Science 321, 1807–1812 (2008).
Mardis, E. R. et al. N. Engl. J. Med. 361, 1058–1066 (2009).
Koivunen, P. et al. Nature 483, 484–488 (2012).
Xu, W. et al. Cancer Cell 19, 17–30 (2011).
Lu, C. et al. Nature 483, 474–478 (2012).
Figueroa, M. E. et al. Cancer Cell 18, 553–567 (2010).
Turcan, S. et al. Nature 483, 479–483 (2012).
Moran-Crusio, K. et al. Cancer Cell 20, 11–24 (2011).
Song, L.-P. et al. Oncogene 27, 519–527 (2008).
Friedman, A. D. Oncogene 21, 3377–3390 (2002).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
H.R.C owns equity in Agios, a biotechnology company developing IDH inhibitors.
Rights and permissions
About this article
Cite this article
Krall, A., Christofk, H. A metabolic metamorphosis. Nature 496, 38–40 (2013). https://doi.org/10.1038/496038a
Published:
Issue Date:
DOI: https://doi.org/10.1038/496038a
- Springer Nature Limited
This article is cited by
-
Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells
Molecular Biology Reports (2022)
-
O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia
Oncogenesis (2020)
-
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
Nature Cell Biology (2017)
-
Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells
Journal of Bioenergetics and Biomembranes (2015)