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Stress mixes chromosomes

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Chromosome-segregation errors during cell division may play a key part in tumour evolution. The long-awaited identification of a common genetic defect causing such errors comes with an interesting conceptual twist. See Letter p.492

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Figure 1: Replication stress causes chromosomal abnormalities.

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Authors and Affiliations

  1. Aniek Janssen and René H. Medema are in the Division of Cell Biology, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.,

    Aniek Janssen & René H. Medema

  2. A.J. is also in the Department of Medical Oncology, University Medical Center Utrecht, the Netherlands,

    Aniek Janssen

  3. R.H.M. is also at the Cancer Genomics Center, the Netherlands.,

    René H. Medema

Authors
  1. Aniek Janssen
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  2. René H. Medema
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Correspondence to René H. Medema.

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Janssen, A., Medema, R. Stress mixes chromosomes. Nature 494, 439–441 (2013). https://doi.org/10.1038/494439a

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