First they sequenced it. Now they have surveyed its hinterlands. But no one knows how much more information the human genome holds, or when to stop looking for it.
References
The ENCODE Project Consortium Nature 489, 57–74 (2012).
International Human Genome Sequencing Consortium Nature 431, 931–945 (2004).
The ENCODE Project Consortium Nature 447, 799–816 (2007).
Thurman, R. E. et al. Nature 489, 75–82 (2012).
Neph, S. et al. Nature 489, 83–90 (2012).
Gerstein, M. B. et al. Nature 489, 91–100 (2012).
Djebali, S. et al. Nature 489, 101–108 (2012).
Sanyal, A., Lajoie, B. R., Jain, G. & Dekker, J. Nature 489, 109–113 (2012).
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Scientfic American: Hidden treasures in ‘junk’ DNA
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Maher, B. ENCODE: The human encyclopaedia. Nature 489, 46–48 (2012). https://doi.org/10.1038/489046a
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DOI: https://doi.org/10.1038/489046a
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