Fat cells are usually thought of as being either energy-storing white fat cells or food-burning brown fat cells. The identification of a third type of fat cell in mice and humans might open up new avenues for combating obesity.
References
Wu, J. et al. Cell 150, 366–376 (2012).
Timmons, J. A. et al. Proc. Natl Acad. Sci. USA 104, 4401–4406 (2007).
Seale, P. et al. Nature 454, 961–967 (2008).
Cannon, B. & Nedergaard, J. Nature 454, 947–948 (2008).
Feldmann, H. M., Golozoubova, V., Cannon, B. & Nedergaard, J. Cell Metab. 9, 203–209 (2009).
Nedergaard, J., Bengtsson, T. & Cannon, B. Am. J. Physiol. 293, E444–E452 (2007).
Cypess, A. M. et al. N. Engl. J. Med. 360, 1509–1517 (2009).
Saito, M. et al. Diabetes 58, 1526–1531 (2009).
van Marken Lichtenbelt, W. D. et al. N. Engl. J. Med. 360, 1500–1508 (2009).
Virtanen, K. A. et al. N. Engl. J. Med. 360, 1518–1525 (2009).
Zingaretti, M. C. et al. FASEB J. 23, 3113–3120 (2009).
Young, P., Arch, J. & Ashwell, M. FEBS Lett. 167, 10–14 (1984).
Cinti, S. et al. J. Histochem. Cytochem. 50, 21–31 (2002).
Guerra, C. et al. J. Clin. Invest. 102, 412–420 (1998).
Petrovic, N. et al. J. Biol. Chem. 285, 7153–7164 (2010).
Aherne, W. & Hull, D. J. Pathol. Bacteriol. 91, 223–234 (1966).
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Cannon, B., Nedergaard, J. Neither brown nor white. Nature 488, 286–287 (2012). https://doi.org/10.1038/488286a
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DOI: https://doi.org/10.1038/488286a
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