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Cardiovascular Biology

Escaped DNA inflames the heart

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High blood pressure can damage heart muscle cells and their mitochondrial organelles. DNA from degraded mitochondria has been shown to trigger inflammation leading to heart failure. See Letter p.251

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Figure 1: A stressed heart cell.

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Authors and Affiliations

  1. Klitos Konstantinidis and Richard N. Kitsis are in the Departments of Medicine and Cell Biology and at the Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York 10461, USA.,

    Klitos Konstantinidis & Richard N. Kitsis

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  1. Klitos Konstantinidis
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  2. Richard N. Kitsis
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Correspondence to Richard N. Kitsis.

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Konstantinidis, K., Kitsis, R. Escaped DNA inflames the heart. Nature 485, 179–180 (2012). https://doi.org/10.1038/485179a

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